CBD also has potential to treat chronic wounds
Another study proving the therapeutic potential of cannabinoids (CBs) for human disease is published by a group of scientists in America.
Scientists suggested that the application of topical cannabinoids would be beneficial for wound healing. Cannabinoids modulated key molecular pathways of wound healing, and notably, CB1R agonism at the non‐healing edge of chronic wounds improved healing via inhibition of the characteristically hyperproliferative keratinocytes found therein.
This could be combined with CB2R agonism in the wound bed to ameliorate the dysregulated inflammatory microenvironment, namely through reduction of pro‐inflammatory cytokines, regulation of MMPs, and shifting from M1 (pro‐inflammatory) to M2 (anti‐inflammatory) macrophage tone.
CBD also has potential to treat chronic wounds, as it exerts generally anti‐inflammatory properties, appears to inhibit the proliferation of hyperproliferative keratinocytes, and has been observed to decrease expression of MMP‐9.
CB2R agonism may be of benefit in acute wound healing by speeding wound closure and reducing fibrosis to potentially lessen or eliminate scarring. Finally, CB2 agonism promotes the survival, proliferation and anti‐inflammatory activity of MSCs which may prove beneficial for acute or chronic wounds.
Weigelt MA, Sivamani R, Lev-Tov H. The therapeutic potential of cannabinoids for integumentary wound management. Exp Dermatol. 2021 Feb;30(2):201-211. doi: 10.1111/exd.14241. Epub 2020 Nov 27. PMID: 33205468.