UV radiation is a well-established environmental risk factor known to cause oxidative stress and disrupt the metabolism of keratinocyte phospholipids so many people are using sunscreen.
Scientists tried to see if cannabidiol (CBD) could be used as a natural sunscreen. CBD is a phytocannabinoid with anti-inflammatory and antioxidant effects.
When CBD was applied on top of the skin of irradiated rats, it increased the level of phosphatidylserines which indicates the prevention of oxidative modification of phospholipids and levels of phosphatidylethanolamines, which may suggest an increase in autophagy and, therefore, reduced effects of oxidative stress. Additionally, CBD, by activating sphingomyelinase, up-regulated the metabolism of sphingomyelin, which lead to increased generation of ceramides. Consequently, CBD also improves the transepidermal barrier, preventing excessive water loss.
CBD can protect living beings from radiation damage.