THC prevent neurodegenerative diseases by improving brain glucose consumption

South African scientists reported an experiment on rat brains showing Cannabis sativa L. tetrahydrocannabinol (THC)-rich extracts improves glucose consumption with concomitant suppression of oxidative stress and cholinergic dysfunction, and modulation of purinergic and gluconeogenic activities in brain tissues.

Erukainure OL, Matsabisa MG, Salau VF, Islam MS. Tetrahydrocannabinol-Rich Extracts From Cannabis Sativa L. Improve Glucose Consumption and Modulate Metabolic Complications Linked to Neurodegenerative Diseases in Isolated Rat Brains. Front Pharmacol. 2020 Nov 24;11:592981. doi: 10.3389/fphar.2020.592981. PMID: 33390972; PMCID: PMC7774498.

Reduced brain glucose consumption arising from impaired glucose uptake and utilization has been linked to the pathogenesis and complications of neurodegenerative diseases.

Great scientists from South Africa verified the ability of Cannabis sativa L. tetrahydrocannabinol (THC)-rich extracts stimulate brain glucose uptake and utilization as well as its modulatory effect on gluconeogenesis, antioxidative, purinergic and cholinergic activities in isolated rats’ brains.

Currently, so many people are suffering from neurodegenerative diseases such as such as Alzheimer’s disease, Parkinson’s disease and HIV dementia.

As I already posted before, US government is holding a patent of cannabinoids as antioxidants and neuroprotectants. This paper showing cannabinoids improves glucose consumption is showing part of the anti-aging part of cannabis.

Cannabis use should be free of patents.

Furthermore, recently, South Korean scientists discovered THC can bind to the main protease of SARS-CoV-2 and blocking its replication which basically disabling the virus. Also, THC was better in blocking the virus propagation than the reference drugs such as Remdesivir, Lopinavir, and Chloroquine.

Vinit Raj, Jae Gyu Park, Kiu-Hyung Cho, Pilju Choi, Taejung Kim, Jungyeob Ham, Jintae Lee,
Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches,
International Journal of Biological Macromolecules, Volume 168, 2021, Pages 474-485, ISSN 0141-8130,

THC have an oral LD50 and toxicity class values of 482mg/kg and IV respectively, which basically means tetrahydrocannabinol is non-toxic and safe.

On 2 Dec 2020, The United Nations Commission on Narcotic Drugs (CND) accepted a World Health Organization (WHO) recommendation to remove cannabis and cannabis resin from Schedule IV of the 1961 Single Convention on Narcotic Drugs by votes.

Unfortunately, People’s Republic of China and 24 other nations voted ‘no’ in this vote, however, I believe Hong Kong Special Administrative Region (HK SAR) can have a different perspective of medical cannabis.

As my sponsor Daily HongKong pointed out, People’s Republic of China can show the world that she is keeping up her promise of ‘One Country Two System’ by acknowledging different perspective of medical use of cannabis and legalize it in a aging society Hong Kong.


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